Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives |
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| Authors: | Vijay S. Patil Kamalakar P. Nandre Sougata Ghosh Vaidya Jayathirtha Rao Balu A. Chopade Sheshanath V. Bhosale Sidhanath V. Bhosale |
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| Affiliation: | 1. Department of Organic Chemistry, North Maharashtra University, Jalgaon 425 001, India;2. Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India;3. Division of Crop Protection Chemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India;4. Institute of Bioinformatics and Biotechnology, University of Pune, Pune 411 007, India;5. School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Vic. 3001, Australia |
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| Abstract: | A series of (2-phenyl-4H-benzopyrimodo[2,1-b][1,3]thiazol-4-yliden-4-yliden)acetonitrile derivatives have been prepared by ring transformation reaction of 4-(methylthio)-2-oxo-6-aryl-2H-pyrane-3-carbonitriles. The yield of ring transformation product is moderate to good. Furthermore the glycosidase inhibitory activities were tested by using α-amylase and α-glucosidase pancreatic, intestinal and liver enzymes, responsible for hyperglycemia in type II diabetes. The results revealed that all compounds exhibit significant glycosidase inhibitory activity. |
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