Effects of morphine on adrenaline responses of uteri from progesterone or estradiol treated mice |
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| Authors: | C G Acevedo E Contreras |
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| Affiliation: | Departamento de Ciencias Fisiológicas (Farmacologia), Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile. |
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| Abstract: | 1. The effect of a chronic morphine treatment on the in vitro contractile responses of the mouse uterus to adrenaline was studied. 2. Chronic morphine treatment induced a supersensitivity state in the uteri from both progesterone and estradiol treated mice. 3. The acute administration of morphine to the uteri from morphine tolerant-dependent and progesterone treated mice induced a further increase of the contractile effect of adrenaline. 4. Reserpine administration did not further increase the supersensitivity of the mouse uterus to adrenaline induced by a chronic morphine treatment. 5. Reserpine suppressed the acute effects of morphine in the uteri from tolerant-dependent mice. |
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