Dendrotoxin-binding brain membrane protein displays a K+ channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations |
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Authors: | H Rehm S Pelzer C Cochet E Chambaz B L Tempel W Trautwein D Pelzer M Lazdunski |
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Institution: | Centre de Biochimie du Centre National de la Recherche Scientifique, Parc Valrose, Nice, France. |
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Abstract: | The purified protein that binds the K+ channel ligands dendrotoxin I and mast cell degranulating peptide can be phosphorylated by cAMP-dependent protein kinase and by an endogenous protein kinase, which may be a specific K+ channel kinase. Phosphorylations take place on the toxin-binding subunit, a polypeptide of 76-80 kDa. Phosphorylation by both kinases leads to activation of the reconstituted dendrotoxin-sensitive K+ channel. |
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