Improving the accuracy of a solid spherical source radius and depth estimation using the diffusion equation in fluorescence reflectance mode |
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| Authors: | Marjaneh Hejazi Florian Stuker Divya Vats Markus Rudin |
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| Affiliation: | 1.Medical Physics and Biomedical Engineering Department, School of Medicine,Tehran University of Medical Sciences,Tehran,Iran;2.Research Center for Science and Technology in Medicine,Tehran University of Medical Sciences, Imam Khomeini Hospital,Tehran,Iran;3.Institute for Biomedical Engineering,University and ETH Zurich,Zurich,Switzerland;4.Institute of Pharmacology and Toxicology,University Zürich,Zurich,Switzerland |
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| Abstract: | Background Non-invasive planar fluorescence reflectance imaging (FRI) is used for accessing physiological and molecular processes in biological tissue. This method is efficiently used to detect superficial fluorescent inclusions. FRI is based on recording the spatial radiance distribution (SRD) at the surface of a sample. SRD provides information for measuring structural parameters of a fluorescent source (such as radius and depth). The aim of this article is to estimate the depth and radius of the source distribution from SRD, measured at the sample surface. For this reason, a theoretical expression for the SRD at the surface of a turbid sample arising from a spherical light source embedded in the sample, was derived using a steady-state solution of the diffusion equation with an appropriate boundary condition. |
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