Terminally differentiating epithelial tissues in primary explant culture: A model of growth and development |
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Authors: | Donald J Merchant |
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Institution: | (1) Department of Microbiology and Immunology, Eastern Virginia Medical School, P. O. Box 1980, 23501 Norfolk, Virginia |
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Abstract: | Summary Many epithelial tissues are characterized by the presence of basal cells which serve the dual roles of self-renewal and of
progression through terminal differentiation, to a functional state. Such tissues, when grownin vitro as primary explants, exhibit a characteristic pattern of outgrowth and development which includes both renewal and efforts
toward normal differentiation. The degree of differentiation achieved depends upon conditions of culture and may be modulated
in a variety of ways. The human prostate constitutes such a system and offers numerous possibilities for investigating basic
control mechanisms in growth and development. Information on a variety of epithelial tissues is reviewed and experimental
results using human prostate tissue are presented.
The work was supported by grant R26 CA 2365, National Cancer Institute. |
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Keywords: | development differentiation function growth progression renewal prostate |
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