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Cat Interferon inhibits Feline Leukaemia Virus Infection in Cell Culture |
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| Authors: | RICHARD RODGERS THOMAS C MERIGAN JUN" target="_blank">WILLIAM D HARDYJUN LLOYD J OLD ROBERT KASSEL |
| Institution: | 1.Division of Infectious Diseases, Department of Medicine,Stanford University School of Medicine,Stanford;2.Division of Immunology,Sloan-Kettering Institute,New York;3.Department of Biochemistry,College of Physicians and Surgeons,New York |
| Abstract: | TRANSMISSION of feline leukaemia can be accomplished with tissue extracts from cases which occur naturally1. Virus particles which are morphologically indistinguishable from the murine and avian C-type viruses are present in cats with the transmitted disease2. Feline leukaemia virus (FeLV) replicates in cat cell cultures3 and infected cells are demonstrable by the indirect immunofiuorescent antibody test which detects FeLV group-specific antigen as granular punctate fluorescence in the cytoplasm of acetone fixed cells4; this method allows easy quantitation of the antiviral effect of interferon. We report the production and assay of feline interferon using the fluorescent antibody test with FeLV infected cat cell cultures. |
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