Design, synthesis and DNA-cleavage of Gly-Gly-His-naphthalene diimide conjugates |
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| Authors: | Steullet V Dixon D W |
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| Affiliation: | Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta 30303, USA. |
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| Abstract: | Naphthalene diimides with one and two metal-chelating Gly-Gly-His (GGH) motifs have been synthesized. Both conjugates induce single-stranded cleavage of plasmid pBR322 DNA in the presence of nickel and Oxone and are approximately 100-fold more efficient than Ni(II) x GH-CONH2 itself. |
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