Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates |
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| Authors: | Koseki Koichi Yamashita Satoshi Takahashi Seiji Koyama Tanetoshi |
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| Institution: | Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, Japan. |
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| Abstract: | In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionite-quenching procedure. |
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