Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution |
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| Authors: | Solomon G Nergadze Marco Andrea Santagostino Alberto Salzano Chiara Mondello Elena Giulotto |
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| Affiliation: | Dipartimento di Genetica e Microbiologia 'Adriano Buzzati-Traverso', Università degli Studi di Pavia, Via Ferrata, 27100 Pavia, Italy. |
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| Abstract: | Background In vertebrates, tandem arrays of TTAGGG hexamers are present at both telomeres and intrachromosomal sites (interstitial telomeric sequences (ITSs)). We previously showed that, in primates, ITSs were inserted during the repair of DNA double-strand breaks and proposed that they could arise from either the capture of telomeric fragments or the action of telomerase. |
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