| 次最低抑菌浓度抗生素对双歧杆菌粘附的影响 |
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| 引用本文： | 郑跃杰,潘令嘉.次最低抑菌浓度抗生素对双歧杆菌粘附的影响[J].中国微生态学杂志,1996,8(5):4-6. |
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| 作者姓名： | 郑跃杰 潘令嘉 |
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| 作者单位： | 广州第一军医大学南方医院全军消化内科研究所 |
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| 摘 要： | 本文观察了八种抗生素在次最低抑菌浓度（Ｓｕｂ－ＭＩＣ）下对双歧杆菌和体外培养肠上皮细胞间粘附的影响。结果表明，次最低抑菌浓度的抗生素均能显著地抑制双歧杆菌的粘附，青霉素和万古霉素对双歧杆菌粘附的抑制有剂量及时间效应。提示抗生素抑制双歧杆菌的粘附可能是其引起肠道微生态失衡的一条重要途径。
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| 关 键 词： | 双歧杆菌，粘附，抗生素 |
EFFECT OF SUBINHIBITORY CONCENTRATIONS OF ANTIBIOTICS ON ADHESION OF HUMAN BIFIDOBACTERIAL STRAINS TO CULTURED HUMAN INTESTINAL EPITHELIAL CELLS |
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| Institution: | (Zheng YueJie,et al.Institute of Gastroenterology of PLA,Guangzhou 510515) |
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| Abstract: | Effect of subinhibitory concentrations of antibiotics on the adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells was investigated. Results showed that subinhibitory concentrations of antibiotice may decrease bifidobacterial adhesion to intestinal epithelial cells in vitro significantly. Penicillin and vancomycin reduced bifidobacterial adhesion to intestinal epithelial cells dose-dependently and time-dependently. The results suggest that antibiotics might influence intestinal bacterial microecology by mechanism of inhibition of bifidobacterial adhesion to intestinal epithelial cells. |
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| Keywords: | Bifidobacteria Adherence Antibiotics |
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