A surrogate-based approach for post-genomic partner identification |
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| Authors: | Renuka C Pillutla Ku-chuan Hsiao Renee Brissette Paul S Eder Tony Giordano Paul W Fletcher Michael Lennick Arthur J Blume Neil I Goldstein |
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| Affiliation: | (1) DGI BioTechnologies, Inc., Edison, NJ, USA;(2) Message Pharmaceuticals, Inc., Malvern, USA |
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| Abstract: | Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present in the human genome. While protein-protein interactions may be central to many disease indications, it has been difficult to identify new chemical entities capable of regulating these interactions as either agonists or antagonists. |
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