Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers |
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Authors: | Liane De Castro Christian Niel Selma A Gomes |
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Institution: | (1) Department of Virology, Oswaldo Cruz Foundation, Av. Brasil 4365, BR-21045-900 Rio de Janeiro, Brazil |
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Abstract: | Background Mutations in the core promoter and precore regions of the hepatitis B virus (HBV) genome, notably the double substitution (AGG to TGA) at nt positions 1762-1764 in the core promoter, and the precore stop codon mutation G to A at nt 1896, can often explain the anti-HBe phenotype in chronic carriers. However, the A1896 mutation is restricted to HBV isolates that have T at nt 1858. The double substitution at positions 1762-1764 has been described to occur preferentially in patients infected with strains showing C instead of T at nt 1858. |
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