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A facile route to paclitaxel C-10 carbamates |
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| Authors: | Ballatore Carlo Aspland Simon E Castillo Rosario Desharnais Joel Eustaquio Trisha Sun Chengzao Castellino Angelo J Smith Amos B |
| Affiliation: | Acidophil, LLC, Suite 250, 10835 Road to the Cure, San Diego, CA 92121, USA. |
| Abstract: | A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2'-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules. |
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