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Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands |
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| Authors: | Bakshi Raman K Hong Qingmei Tang Rui Kalyani Rubana N Macneil Tanya Weinberg David H Van der Ploeg Lex H T Patchett Arthur A Nargund Ravi P |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. Raman_bakshi@merck.com |
| Abstract: | Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed. |
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