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Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands
Authors:Bakshi Raman K  Hong Qingmei  Tang Rui  Kalyani Rubana N  Macneil Tanya  Weinberg David H  Van der Ploeg Lex H T  Patchett Arthur A  Nargund Ravi P
Affiliation:Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. Raman_bakshi@merck.com
Abstract:Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.
Keywords:
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