In vivo effects of single or combined dietary antimutagens on mutagen-induced chromosomal aberrations |
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Authors: | H W Renner |
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Affiliation: | Federal Research Centre for Nutrition, Karlsruhe, F.R.G. |
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Abstract: | The food components chlorophyllin, beta-carotene and alpha-linolenic acid (in its methyl ester form) were tested in Chinese hamsters for antimutagenic activity on the powerful mutagen thio-tepa. Each of these natural protective compounds inhibited by 70-85% the clastogenic effects induced by the mutagen. When 2 or 3 of these antimutagens were administered simultaneously no additive effects were observed. alpha-Linolenic acid methyl ester was the most effective antimutagen under the experimental conditions. |
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