Lipase-catalyzed acetylation of N-acetylneuraminic acid derivative |
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| Authors: | Lo L C Hsiao K F Ueng S H Wu S H |
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| Institution: | Department of Chemistry, National Taiwan University, Taipei. |
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| Abstract: | A facile preparation of triacetylated derivative of 2-phenylthioglycoside of N-acetylneuraminic acid (4) was achieved by treatment with lipase PS in vinyl acetate. The major product 4 has a free hydroxyl group at C-7. Results of time-course HPLC analysis indicate that the reactivity of the hydroxyl groups under this condition is in the following order; C-9 > C-4 > C-8 > C-7. |
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