Clinical, hormonal and semiological data in adult men operated in childhood for hypospadias

Examination of 16 adult men operated in childhood for hypospadias revealed signs of moderate injury of the male genital system. It appears that accessory sexual glands were mainly responsible for the observed abnormalities. Since testicular position and size, serum testosterone and FSH levels were normal it seems that hypospadias and the accompanied disturbances are connected with reduction of responsiveness of target tissues to androgen stimuli rather, than with lesion of the testicle. The coexistence of normal serum testosterone and elevation of serum LH suggests the decrease of sensitivity of hypothalamic or pituitary receptors to negative feedback influence of androgens. The consciousness of sexual inadequacy noted in some cases was mainly of emotional character.