Evolution of EF-hand calcium-modulated proteins. III. Exon sequences confirm most dendrograms based on protein sequences: Calmodulin dendrograms show significant lack of parallelism |
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Authors: | Susumu Nakayama Robert H. Kretsinger |
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Affiliation: | (1) Department of Biology, University of Virginia, 22901 Charlottesville, VA, USA;(2) Present address: Department of Biochemistry, Nagasaki University School of Medicine, 12-4 Sakamoto-machi, 852 Nagasaki, Japan |
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Abstract: | Summary In the first report in this series we presented dendrograms based on 152 individual proteins of the EF-hand family. In the second we used sequences from 228 proteins, containing 835 domains, and showed that eight of the 29 subfamilies are congruent and that the EF-hand domains of the remaining 21 subfamilies have diverse evolutionary histories. In this study we have computed dendrograms within and among the EF-hand subfamilies using the encoding DNA sequences. In most instances the dendrograms based on protein and on DNA sequences are very similar. Significant differences between protein and DNA trees for calmodulin remain unexplained. In our fourth report we evaluate the sequences and the distribution of introns within the EF-hand family and conclude that exon shuffling did not play a significant role in its evolution. |
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Keywords: | EF-hand Calcium-binding protein Gene duplication Congruence Domain transposition Calmodulin cDNA Genomic DNA |
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