Evidence for a hepatocellular lineage in a combined hepatocellular-cholangiocarcinoma of transitional type |
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Authors: | H-P Fischer W Doppl M Osborn M Altmannsberger |
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Institution: | 1. Department of Pathology, Justus Liebig University Gie?en, Langhansstra?e 10, D-6300, Gie?en, Federal Republic of Germany 2. Department of Medicine III, Justus Liebig University Gie?en, Rodthohl 6, D-6300, Gie?en, Federal Republic of Germany 3. Max Planck Institute for Biophysical Chemistry, D-3400, G?ttingen, Federal Republic of Germany
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Abstract: | A combined hepatocellular-cholangiocarcinoma (CHC) of transitional subtype and the surrounding cirrhotic liver tissue were
investigated immunocytochemically by monoclonal antibodies specific for each of the keratin polypeptides 7, 8, 18 and 19.
Different keratin subsets were found in different parts of the tumour. The hepatocellular component reveals keratins 8 and
18, with the bordering cells of trabecular formations additionally expressing keratins 7 and 19. The same keratins i.e. 7,
8, 18, 19 were found in normal bile duct epithelium as well as in cholangiocarcinomatous and transitional areas of hepatocellular
and cholangiocellular differentiation. Normal hepatocytes express only keratin 8 and 18. In cirrhotic liver some modified
hepatocytes additionally express keratin 7. When ductal transformation is observed in the marginal parts of portal tracts
and fibrous septa the keratin polypeptide pattern mimics that of bile duct epithelium. The cholangiocellular metaplasia of
hepatocytes observed here correlates well with findings in hepato-organogenesis and hepatocarcinogenesis and suggests that
the transitional subtype of combined hepatocellular-cholangiocarcinoma is a variant of hepatocellular carcinoma. |
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Keywords: | Combined hepatocellular-cholangiocarcinoma Histogenesis |
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