Convenient synthesis of GOLD and MOLD and identification of their oxidation products in vitro and in vivo |
| |
Authors: | M. D. Linetsky E. V. Shipova |
| |
Affiliation: | (1) Mason Eye Institute, University of Missouri-Columbia, Columbia, Missouri, U.S.A. |
| |
Abstract: | Summary. Two Lys–Lys crosslinks, 1,3-bis-(5-amino-5-carboxypentyl)-1H-imidazolium (GOLD) and 1,3-bis(5-amino-5-carboxypentyl)-4-methyl-1H-imidazolium (MOLD) salts, have been synthesized by the reaction of imidazole or 4(5)-methyl imidazole with 5-(4-bromobutyl)-hydantoin followed by the hydrolysis of 1,3-substituted imidazolium derivatives by 6.0 N HCL at 110 °C. Treatment of GOLD and MOLD with hydrogen peroxide in acetic acid leads to MOLD oxidation only. The oxidation product of MOLD was detected in cataractous lens proteins. |
| |
Keywords: | : Advanced Glycation End Products (AGEs) – GOLD – Lysine crosslinks – Maillard reaction – MOLD |
本文献已被 PubMed SpringerLink 等数据库收录! |
|