Involvement of aeration in carbon source regulation of cephem antibiotic biosynthesis inStreptomyces clavuligerus |
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| Authors: | A. F. Brana W. -S. Hu A. L. Demain |
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| Affiliation: | (1) Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, 02139 Cambridge, MA |
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| Abstract: | Summary The interference by glycerol and other carbon sources with production of cephem antibiotics by resting cells ofStreptomyces clawligerus was found to be related to aeration conditions. When a low cell density or increased aeration was used, carbon sources did not have any effect on the rate of production. |
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