A mathematical model of adult GnRH neurons in mouse brain and its bifurcation analysis |
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Authors: | Duan Wen Lee Kiho Herbison Allan E Sneyd James |
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Institution: | a Department of Mathematics, University of Auckland, Auckland 1142, New Zealand b Centre for Neuroendocrinology and Department of Physiology, University of Otago, Dunedin 9054, New Zealand |
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Abstract: | GnRH neurons are hypothalamic neurons that secrete gonadotropin-releasing hormone (GnRH) which stimulates the release of gonadotropins, one of the crucial hormones for sexual development, fertility and maturation. A mathematical model was built to help elucidate the mechanisms underlying electrical bursting and synchronous Ca2+] transients in GnRH neurons (Lee et al., 2010). The model predicted that bursting in GnRH neurons (at least of the short-bursting type) requires the existence of a Ca2+]-dependent slow after-hyperpolarisation current (sIAHP-UCL), and this predicted current was found experimentally. GnRH behaviour under a wide range of conditions (inhibition of Na+ channels, IP3 receptors, Ca2+]-dependent K+ channels, or Ca2+ pumps, or in the presence of zero extracellular Ca2+]) is successfully reproduced by the model. In this paper, a simplified version of the previous model, with the same qualitative behaviour, is constructed and studied using timescale separation techniques and bifurcation analysis. |
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Keywords: | Bursting Calcium dynamics After hyperpolarisation current Timescale separation |
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