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| 二级结构组件与蛋白质耐热性的关系研究 | |
| 引用本文： | 丁彦蕊,蔡宇杰,孙俊,须文波. 二级结构组件与蛋白质耐热性的关系研究[J]. 生物信息学, 2007, 5(3): 106-108 |
| 作者姓名： | 丁彦蕊 蔡宇杰 孙俊 须文波 |
| 作者单位： | 1. 江南大学信息工程学院,无锡,214122;江南大学工业生物技术教育部重点实验室,无锡,214036 2. 江南大学工业生物技术教育部重点实验室,无锡,214036;江南大学生物工程学院,无锡,214096 3. 江南大学信息工程学院,无锡,214122 |
| 摘 要： | 挑选了NCBI COG数据库中具有全基因组的单细胞微生物,选择其中三维结构已知的蛋白质作为研究对象,研究了不同类型的二级结构含量和长度对古细菌和细菌类蛋白质耐热性的影响作用。结果表明:耐热的古细菌类蛋白质中含有相当数量的短的3_(10)螺旋,而耐热的细菌蛋白质中含有较短的loop环。这不仅说明二级结构对蛋白质耐热性有重要的影响,还表明二级结构对古细菌和细菌类蛋白质耐热性的影响作用是不同的。 |
| 关 键 词： | 蛋白质 耐热性 二级结构 |
| 文章编号： | 1672-55SS（2007）-03-106-03 |
| 修稿时间： | 2006-09-04 |
Research on the relationship between secondary structure element and protein thermostability |
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| DING Yan-rui,CAI Yu-jie,SUN Jun,XU Wen-bo. Research on the relationship between secondary structure element and protein thermostability[J]. Chinese Journal of Bioinformatics, 2007, 5(3): 106-108 | |
| Authors: | DING Yan-rui CAI Yu-jie SUN Jun XU Wen-bo |
| Affiliation: | 1.School of information technology,Southem Yangtx University,Jiangsu Wuxi 214122,China;2.Key Laboratory of Industrial Biotechnology,Jiangsu Wuxi 214036,China;3.School of biatechnolgy,Jiangsu Wuxi 214036,China |
| Abstract: | In this paper,we selected all complete genome unicellular microorganisms from NCBI COG database,and collected all proteins whose three-dimensional structure had been measured to study the influence of secondary structure property (compositon and length) on ar- chaeal and bacterial protein thermostability.The results show:there are plenty d short 310 helixes in thermophilic archaeal proteins,while there are some short loops in thermophilc bacterial proeins.From the result,we can conclude that secondary struture property have important influence on protein thermostability,but the influence on archael protein is different from bacteroal protein. |
| Keywords: | protein thermostability secondary structure |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |