Electron paramagnetic resonance studies of iron-sulfur centers in mitochondria prepared from three Morris hepatomas with different growth rates |
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Authors: | T Onishi J G Hemington K F LaNoue H P Morris J R Williamson |
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Institution: | Johnson Research Foundation, University of Pennsylvania Philadelphia, Pennsylvania 19174, USA |
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Abstract: | Iron-sulfur centers in mitochondria prepared from Morris hepatomas with different growth rates were compared with those in host liver and nontumor-bearing rat liver mitochondria by EPR measurements (< 77° K). In the slow growing hepatoma 16, EPR signals from iron-sulfur centers located in the NADH dehydrogenase region were specifically diminished. In the rapidly growing hepatoma 7777, EPR signals of all the iron-sulfur centers showed considerably diminished intensity. In hepatoma 7800 having an intermediate growth rate, all iron-sulfur centers showed no change. Those changes in iron-sulfur centers correlated with observed respiratory activities of Morris hepatoma mitochondria. No general correlation was obtained between these parameters and the growth rate of the tumors. |
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