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微生物产色素机制及其生物活性
引用本文:于雪,张威,吴玉洁,陈拓,刘光琇.微生物产色素机制及其生物活性[J].微生物学报,2022,62(4):1231-1246.
作者姓名:于雪  张威  吴玉洁  陈拓  刘光琇
作者单位:中国科学院西北生态环境资源研究院, 沙漠与沙漠化重点实验室, 甘肃 兰州 730000;中国科学院西北生态环境资源研究院, 甘肃省极端环境微生物资源与工程重点实验室, 甘肃 兰州 730000;中国科学院大学, 北京 100049;中国科学院西北生态环境资源研究院, 甘肃省极端环境微生物资源与工程重点实验室, 甘肃 兰州 730000;中国科学院西北生态环境资源研究院, 冰冻圈科学国家重点实验室, 甘肃 兰州 730000;中国科学院大学, 北京 100049
基金项目:国家重点研发计划政府间国际科技创新合作专项(2019YFE0121100);国家自然科学基金(31870479);甘肃省科技计划(18JR2TA019,20YF3WA007)
摘    要:近年来,随着人工合成色素的大量使用引起一系列环境和健康问题,增加了人们对安全、无毒天然色素的需求。天然色素主要来源于植物和微生物,由于植物生长周期较长使植物源色素在大规模应用中受限。与植物源天然色素相比,微生物源色素易于大规模快速培养,具有更广阔的应用前景。本文系统总结了不同微生物源色素产生机制,及其在抗菌、抗氧化及抗癌等生物医药领域的研究进展,并对其面临的问题及未来的发展进行了展望。

关 键 词:微生物  色素  生物合成机制  生态适应机制  生物活性
收稿时间:2021/8/5 0:00:00
修稿时间:2021/11/25 0:00:00

Production mechanism and biological activity of microbial pigments
YU Xue,ZHANG Wei,WU Yujie,CHEN Tuo,LIU Guangxiu.Production mechanism and biological activity of microbial pigments[J].Acta Microbiologica Sinica,2022,62(4):1231-1246.
Authors:YU Xue  ZHANG Wei  WU Yujie  CHEN Tuo  LIU Guangxiu
Institution:Key Laboratory of Desert and Desertification, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China;University of Chinese Academy of Sciences, Beijing 100049, China;Key Laboratory of Extreme Environmental Microbial Resources and Engineering, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China;State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, Gansu, China;University of Chinese Academy of Sciences, Beijing 100049, China
Abstract:The environmental and health problems caused by the massive use of synthetic pigments in recent years increase the demand for safe,non-toxic natural pigments.Natural pigments are mainly derived from plants and microorganisms.However,the large-scale application of plant-derived pigments is limited by the long growth cycle of plants.Compared with plants,microorganisms are easy to be cultivated on a large scale in a short time and thus microorganism-derived pigments have a broad application prospect.We systematically summarized the production mechanisms,reviewed the research progress in the antibacterial,anti-oxidation and anti-cancer activities,and put forward the opportunities and challenges in the development of microorganism-derived pigments.
Keywords:microorganism  pigment  biosynthesis mechanism  ecological adaptation mechanism  biological activity
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