链霉菌的全局调控蛋白DasR

链霉菌能够产生多种次级代谢产物,在临床、农牧业、生物技术等领域具有重要应用价值;对链霉菌的调控网络进行深入研究有助于提高次级代谢产物产量并发现新的次级代谢产物.链霉菌中次级代谢产物生物合成按调控通路分为全局调控与途径特异性调控,其中全局调控蛋白可靶向多种通路特异调控基因和生物合成基因,在链霉菌的生命活动中发挥着更为普遍...

Global regulatory protein DasR in Streptomyces

Streptomycetes produce a variety of secondary metabolites,which are highly valuable in clinical practice,agriculture,animal husbandry,biotechnology,etc.The research on the regulatory networks of secondary metabolites in Streptomycetes will improve their yields and facilitate the discovery of novel secondary metabolites.The biosynthesis of secondary metabolites in Streptomycetes can be regulated in a global or pathway-specific manner.The global regulators can target multiple pathway-specific genes and biosynthesis genes,playing a universal and complicated role.Therefore,studying the global regulation will improve the understanding of the complicated regulation networks in Streptomycetes.DasR,a global regulator,plays a key role in the nutrient sensing,morphological changing,and secondary metabolism.In this review,we summarized the structure,sequence,and function of DasR,and reviewed the research findings on role of DasR in the growth,secondary metabolism,nutrient sensing,and primary metabolism of Streptomycetes.