肠道微生物与血清素互作研究进展

肠道微生物在肠道稳态和大脑健康中发挥着举足轻重的作用.血清素是大脑的一种重要的单胺类神经递质,90％以上在结肠肠嗜铬细胞中由色氨酸代谢转化而来,在机体发挥广泛作用.近年来的研究表明,血清素对机体发挥的作用可能受到肠道微生物影响.肠道中某些微生物具有产生血清素的能力,同时,微生物群及其代谢产物(如丁酸)能通过影响色氨酸羟...

Research advances in interaction between gut microbiota and serotonin

Gut microbiota plays an essential role in intestinal homeostasis and brain health.Serotonin is an important monoamine neurotransmitter in the brain.More than 90% of serotonin is converted from tryptophan metabolism in colonic enterochromaffin cells and exerts system-wide regulations.Recent studies have demonstrated that the effects of serotonin may be affected by gut microbiota.Specific microbes in the gut have the ability to produce serotonin.The gut microbiota and its metabolites,such as butyric acid,can regulate the level of serotonin by affecting the activity of tryptophan hydoxylase or the metabolism of tryptophan.In turn,serotonin and serotonin reuptake inhibitors can modulate the composition and function of gut microbiota.The gut microbiota-serotonin interaction is of great significance to the host health,and the mechanism underlying the interaction remains to be elucidated.This article reviews the research progress on gut microbiota,serotonin,and their interaction,aiming to provide references for in-depth investigation on how the gut microbiota-serotonin interaction regulates gut and brain health.