beta-N-gamma-glutamyl diaminopropionic acid, a convulsant and an inhibitor of brain glutamate decarboxylase |
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Authors: | S J Kazi S L Rao |
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Institution: | Department of Biochemistry, Osmaniu University, Hyderabad, India |
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Abstract: | The different isomers of the dipeptide beta-N-gamma-glutamyl diaminopropionate inhibit L-glutamate-1-carboxylyase (GAD, EC-4.1.1.15) activity in mouse brain homogenates. The L-D isomer is the most effective as an inhibitor, while the D-D isomer is least inhibitory. The different isomers are neurotoxic to mice and the chick, the L-D isomer being the most toxic. The neurotoxicity of the isomers in mice was also associated with a significant lowering in GAD activity in the brains of convulsing mice. |
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Keywords: | γ-Glutamyl diaminopropionate Neurotoxic peptide GAD inhibitor |
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