Tuning Multiple Motor Travel via Single Motor Velocity |
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Authors: | Xu Jing Shu Zhanyong King Stephen J Gross Steven P |
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Affiliation: | Developmental and Cell Biology, School of Biological Sciences, University of California, Irvine, CA, 92697, USA; School of Natural Sciences, University of California, Merced, CA, 95343, USA. |
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Abstract: | Microtubule-based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple-motor-based motion to various single molecule properties. Whereas both single-motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single-motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between single-motor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single-motor velocity in regulating multiple-motor transport. |
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Keywords: | cargo travel kinesin multiple‐motor transport transport regulation velocity |
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