Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy |
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| Authors: | Zhang Zijuan Kwiatkowski Nicholas Zeng Hong Lim Sang Min Gray Nathanael S Zhang Wei Yang Priscilla L |
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| Institution: | Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, Massachusetts 02125, USA. wei2.zhang@umb.edu. |
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| Abstract: | As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy. |
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