Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin |
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| Authors: | Kudo Shota Caaveiro Jose M M Miyafusa Takamitsu Goda Shuichiro Ishii Keisuke Matsuura Tadashi Sudou Yukio Kodama Tatsuhiko Hamakubo Takao Tsumoto Kouhei |
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| Affiliation: | Department of Medical Genome Sciences, The University of Tokyo, Tokyo 108-8639, Japan. |
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| Abstract: | Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2? was not necessary for dimerization, although it greatly stabilized the protein-protein complex. |
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