Leptin and OB-R: Body weight regulation by a cytokine receptor |
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Authors: | David W. White Louis A. Tartaglia |
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Affiliation: | Millennium Pharmaceuticals, 640 Memorial Drive, Cambridge, MA 02139, U.S.A. |
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Abstract: | There has been intense recent interest in the molecules and pathways governing mammalian body weight regulation. Leptin (OB), an ancestral member of the cytokine family, is an adipocyte-secreted circulating hormone exhibiting weight regulatory properties. Recently, the leptin receptor (OB-R) was identified and shown to exhibit sequence homology and functional similarity to members of the class I cytokine receptor family. The mechanisms governing OB-R triggering and signal transduction have begun to be elucidated, providing new insight into the pathways controlling mammalian body weight homeostasis. |
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Keywords: | Obesity Leptin (OB) Leptin receptor (OB-R) Hypothalamus Signal transduction |
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