Rapid polyphosphoinositide decrease is an early event in the steroidogenic response of bovine adrenocortical fasciculata cells to angiotensin II |
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Authors: | A J Hadjian M Culty E M Chambaz |
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Affiliation: | Laboratoire de Biochimie Endocrinienne, INSERM - U 244, CNRS - ERA 942, Université Scientifique et Médicale de Grenoble, B.P. 68, 38402 Saint-Martin-d''Hères Cédex, France |
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Abstract: | Addition of angiotensin II (0.3 microM) to bovine adrenal fasciculata cell suspensions prelabeled with [32P] induced a rapid (15 seconds) and marked decrease of the radioactivity from phosphatidylinositol 4,5-biphosphate (62%) and phosphatidylinositol 4-monophosphate (35%). This effect was concentration-dependent and specifically inhibited in the presence of (Sar1-Ala8)-angiotensin II; it was also completely prevented in the absence of extracellular calcium. The present data appear to illustrate the earliest biological response detectable in bovine fasciculata cells under angiotensin II challenge. |
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