Insulin stimulation of GLUT-4 translocation: a model for regulated recycling |
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Authors: | James D E Piper R C Slot J W |
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Affiliation: | Centre for Molecular Biology and Biotechnology, University of Queensland, St Lucia, Brisbane 4072, Australia. |
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Abstract: | Insulin stimulates glucose transport in muscle and fat cells by causing the redistribution of a facilitative glucose transporter, GLUT-4, from an intracellular compartment to the cell surface. But what is this intracellular GLUT-4 compartment? It may be a specialized compartment, perhaps analogous to synaptic vesicles, or may simply be part of the endosomal system. Other constituents of this compartment might be regulators of GLUT-4 movement to the cell surface, and their identification should make it possible to find the link between the insulin signal transduction pathway and GLUT-4 translocation. |
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