Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction |
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Authors: | Kawakami Makiko Harada Nobuhiro Hiratsuka Mio Kawai Kiyoshi Nakamura Yoshimasa |
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Affiliation: | Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Japan. |
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Abstract: | We found that both benzyl isothiocyanate (ITC) and phenyl ITC inhibited respiration in the mitochondria in an electrophilic reaction-dependent manner. ITC-induced mitochondrial swelling and cytochrome c release were prevented by cyclosporin A, indicating that they are mediated through the ITC moiety-dependent reaction to critical thiol groups for the opening of membrane permeability transition-dependent pores. |
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