Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction |
| |
| Authors: | Kawakami Makiko Harada Nobuhiro Hiratsuka Mio Kawai Kiyoshi Nakamura Yoshimasa |
| |
| Affiliation: | Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Japan. |
| |
| Abstract: | We found that both benzyl isothiocyanate (ITC) and phenyl ITC inhibited respiration in the mitochondria in an electrophilic reaction-dependent manner. ITC-induced mitochondrial swelling and cytochrome c release were prevented by cyclosporin A, indicating that they are mediated through the ITC moiety-dependent reaction to critical thiol groups for the opening of membrane permeability transition-dependent pores. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
