| 新疆蒙古族、锡伯族新生儿HbF中Gγ/Aγ、AγI/AγT比值测定及基因图谱分析 |
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| 引用本文： | 钱渡,光炜,庄怡,马梅荪,陈松森,陈卫东,梁植权,周静QIAN Du,GUANG Wei,ZHAUNG Yi,MA Mei-Sun,CHEN Song-Sen,CHEN Wei-Dong,LIANG Zhi-Quan,ZHOU Jing.新疆蒙古族、锡伯族新生儿HbF中Gγ/Aγ、AγI/AγT比值测定及基因图谱分析[J].遗传,1996,18(2):39-42. |
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| 作者姓名： | 钱渡 光炜 庄怡 马梅荪 陈松森 陈卫东 梁植权 周静QIAN Du GUANG Wei ZHAUNG Yi MA Mei-Sun CHEN Song-Sen CHEN Wei-Dong LIANG Zhi-Quan ZHOU Jing |
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| 作者单位： | 1.新疆医学院生物学教研室, 乌鲁木齐 830054
2.中国医学科学院基础医学研究所，北京 100005
3.新疆巴音郭楞蒙古族自治州卫生学校，新疆841000
1.epartment of Biology,Xinjiang Medical College,Urumuqi 830054
2.Basic Medical Research Institute,Chinese Academy of Medical Sciences,Beijing 100005
3.Health School of Bayinguoleng Mongol Autonomous Prefecture,Xinjiang 841000 |
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| 摘 要： | 用HPLC法测定新疆蒙古族78例、锡伯族60例新生儿胎儿血红蛋白(HbF)中Gγ/Aγ以及AγI/AγT比值。%Gγ均值为:蒙古族73.99% ,锡伯族74.59%。%AγI均值分别为蒙古族56.04%和锡伯族64.33%。在蒙古族中发现AγT纯合体4例、杂合体12例;锡伯族中发现AγT杂合体6例。蒙古族中AγT基因频率(fAγT)为0.128,锡伯族为0.05。
Abstract: Gγ/Aγ、AγI/Aγ Ratios of fetal hemoglobin(HbF) in 138 cases of newborns of Megnol (n=78)and Sibo(n=60)ethnic groups in Urumuqi,Xinjiang were determined by HPLC.The means of % Gγ of Mongol and sibo ethnic groups were 73.99% and 7459% respectively.12 Aγ/T cases of heterozygotes in Mongol,6 in Sibo and 4 cases of AγT homozygotes in Mongol were found.The frequencies of AγT gene were 0.128 in Mongol and 0.05 in Sibo respectively.The means of AγT of Mongol and Sibo ethnic groups were 56.04% and 64.33% respectively.
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| 关 键 词： | 高效液相色谱法(HPLC) Gγ/Aγ比值 族 蒙古 AγT基因频率 |
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