Use of cell recycle in the aerobic fermentative production of citric acid by yeast |
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Authors: | J D Enzminger J A Asenjo |
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Institution: | (1) Biochemical Engineering Laboratory Department of Chemical Engineering and Applied Chemistry, Columbia University, 10027 New York, NY |
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Abstract: | Summary An aerobic continuous stirred tank bioreactor with cell recycle was used to produce citric acid from glucose with a yeastSaccharomycopsis lipolytica NRRL Y7576. Specific rate of total acid production was 0.045h–1, yield on glucose was 0.86 g/g and volumetric productivity was 1.16 g acid/Lh; all higher than or similar to batch values. Effluent acid concentration was 75g/L. In batch, under nitrogen limited. conditions, stability of citric acid synthesis and excretion was constant over a period of 700 hours. Under conditions of cell recycle, cell concentration and rate of acid production were constant over 200 hours of operation. |
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