Accurate peak list extraction from proteomic mass spectra for identification and profiling studies |
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Authors: | Nicola Barbarini Paolo Magni |
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Affiliation: | 1.Dipartimento di Informatica e Sistemistica,Università degli Studi di Pavia,Pavia,Italy |
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Abstract: | Background Mass spectrometry is an essential technique in proteomics both to identify the proteins of a biological sample and to compare proteomic profiles of different samples. In both cases, the main phase of the data analysis is the procedure to extract the significant features from a mass spectrum. Its final output is the so-called peak list which contains the mass, the charge and the intensity of every detected biomolecule. The main steps of the peak list extraction procedure are usually preprocessing, peak detection, peak selection, charge determination and monoisotoping operation. |
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