Effects of dehydroepiandrosterone on passive avoidance in ovariectomized female rats of different age |
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| Authors: | Goncharov N P Fedotova Iu O Sapronov N S |
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| Affiliation: | Institute for Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg. |
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| Abstract: | The aim of the present work was to study the influence of long-term treatment with dehydroepiandrosterone (DHEA) in doses of 0.1 and 0.7 mg/kg, i.p. on the passive avoidance performance in the ovariectomized female rats of 5- and 18-month old. The results obtained indicated that DHEA administration during 7 days in dose of 0.1 mg/kg normalized the passive avoidance performance in the ovariectomized rats of 5-month old while DHEA administration during 7 days in dose of 0.7 mg/kg restored passive avoidance performance in the ovariectomized rats of 18-month old. |
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