Effect of atrial natriuretic peptide on renin release in rat isolated glomeruli |
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| Authors: | S Kageyama J Brown |
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| Affiliation: | Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K. |
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| Abstract: | Effects of atrial natriuretic peptide (ANP) on renin release in isolated rat glomeruli were investigated. ANP suppressed renin release by 25% at 5 x 10(-8) M when glomeruli were incubated in a medium containing 1.26 mM calcium (p = 0.0019). When glomeruli were incubated in a calcium free medium containing 2 mM EGTA, ANP suppressed stimulated renin release significantly at 5 x 10(-8) and 5 x 10(-9) M by 25% (p = 0.0204, and p = 0.0101, respectively). These results indicate that ANP suppresses renin release in a dose dependent manner, probably through a calcium independent process. |
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