Mitochondrial and lysosomal pathways of lamprey (Lampetra fluviatilis L.) hepatocyte death |
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Authors: | S. A. Konovalova M. V. Savina A. A. Nikiforov L. V. Puchkova |
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Affiliation: | 1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia 2. Department of Biophysics, Physico-Mechanical Faculty, St. Petersburg State Polytechnical University, St. Petersburg, Russia
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Abstract: | Mechanisms of mitochondrial and lysosomal pathways of natural death of lamprey hepatocytes are described at the spring period of the prespawn migration. The mitochondrial pathway (release of cytochrome c from mitochondria into cytosol and activation of caspases) is realized by the classic scheme of apoptosis. Comparatively recently, the lysosomal pathway of cell death associated with cathepsin B activation has been revealed in cells in pathologies, specifically in obstruction of gallbladder and bile ducts. A peculiarity of lamprey hepatocytes consists in that in the adult animal liver there takes place biliary atresia (the absence of gallbladder and bile ducts. Thereby, the lamprey hepatocytes are an excellent object for study of this new pathway of cell death. We have revealed development of the mitochondrial and the lysosomal pathways of cell death of lamprey hepatocytes. |
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