Development of a multiciliated cell |
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| Institution: | 1. Department of Medicine (Nephrology Division), Washington University, St Louis, MO, USA;2. Department of Cell Biology and Physiology, Washington University, St Louis, MO, USA;1. Department of Systems Biology, Blavatnik Institute at Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA;2. Department of Radiation Oncology, Dana-Farber Brigham Cancer Center, 75 Francis St, Boston, MA 02115, USA;3. Ludwig Center at Harvard, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215, USA;1. Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands;2. Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia;1. Stanford University School of Medicine, Baxter Laboratory, Departments of Microbiology and Immunology and Pathology, Stanford, CA 94305, USA;2. Stanford University School of Medicine, Department of Radiation Oncology and Department of Genetics, Stanford, CA 94305, USA;1. Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, NC 27599, USA;2. Biology Department, University of North Carolina, Chapel Hill, NC 27599, USA;3. Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;4. Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA;5. Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA;6. Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA;7. Assistance Publique-Hôpitaux de Paris, Service de Pneumologie et Allergologie Pédiatriques, Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris 75015, France;8. Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Childhood Genetic Disorders, Département de Génétique Médicale, Assistance Publique-Hôpitaux de Paris, Hôpital Trousseau, Paris 75012, France;9. Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA;1. Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan;2. Department of Neurological Surgery, and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA |
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| Abstract: | Multiciliated cells (MCC) are evolutionary conserved, highly specialized cell types that contain dozens to hundreds of motile cilia that they use to propel fluid directionally. To template these cilia, each MCC produces between 30 and 500 basal bodies via a process termed centriole amplification. Much progress has been made in recent years in understanding the pathways involved in MCC fate determination, differentiation, and ciliogenesis. Recent studies using mammalian cell culture systems, mice, Xenopus, and other model organisms have started to uncover the mechanisms involved in centriole and cilia biogenesis. Yet, how MCC progenitor cells regulate the precise number of centrioles and cilia during their differentiation remains largely unknown. In this review, we will examine recent findings that address this fundamental question. |
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