Influence of operational variables on properties of piroxicam pellets prepared by extrusion-spheronization: A technical note |
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Authors: | Vivek R Sinha Manoj K Agrawal Rachna Kumria Jayant R Bhinge |
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Institution: | (1) University Institute of Pharmaceutical Sciences, Panjab University, 160014 Chandigarh, India;(2) Ranbaxy Laboratories Ltd, Paonta Sahib, India;(3) Ind-Swift Laboratories Ltd, Parwanoo, India |
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Abstract: | Summary and Conclusion The processing conditions has a pronounced effect on the pellet properties. Drying conditions influenced the mean size and
the drug release of the pellets. Because of the shrinking of the pellets upon drying at higher temperatures, the pellets also
showed increased densities. Freeze drying almost prevented shrinking and thus led to the highest drug release. With an increase
in the temperature of drying, the drug release rate decreased.
Both spheronization time and spheronization speed affected the shapes of pellets, and the changes in shapes then affected
the pellet flow properties. Within the studied range, the circularity of the pellets was affected more by the spheronization
time than by the spheronization speed. Drying conditions influenced pellet friability, which decreased with an increase in
drying temperature, indicating the formation of more dense structures at higher temperatures. The same result was obtained
with spheronization time. With an increase in spheronization time, the friability decreased, because of the formation of more
compact masses at higher spheronization time. Mean size was not affected by spheronization time or spheronization speed.
Published: March 9, 2007 |
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Keywords: | Extrusion spheronization pellets microcrystalline cellulose |
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