Design and synthesis of novel antibacterial peptide-resin conjugates |
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Authors: | Cho Won-Mi Joshi Bishnu Prasad Cho Hyeongjin Lee Keun-Hyeung |
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Affiliation: | Bioorganic Chemistry Laboratory, Department of Chemistry, Inha University, 253 Younghyong-Dong, Nam-Gu, Inchon-City 402-751, South Korea. |
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Abstract: | We synthesized a novel peptide-resin conjugate by immobilizing beta-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism with vancomycin. Specially, the peptide-resin conjugate showed a more increased lipid membrane perturbation activity in comparison to unbound beta-sheet antibacterial peptide. |
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