Cyclocreatine Phosphate, an Analogue of Creatine Phosphate, Does not Improve Hypoxic Tolerance in Mice |
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Authors: | Alan A Artru John D Michenfelder |
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Institution: | Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, U.S.A. |
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Abstract: | Abstract: Dietary cyclocreatine has been reported to increase brain highenergy stores in mice and to prolong the generation and utilization of these stores following decapitation. A possible cerebral protective action after 50 days of dietary cyclocreatine 0.5% and 1.0% was therefore examined in mice. Cyclocreatine 0.5% did not increase survival time during hypoxia (5% 02). Cyclocreatine 1.O% in the absence of hypoxia caused significant mortality and decreased weight in survivors despite prophylactic antibiotic treatment. Dietary cyclocreatine offers no cerebral protection against hypoxia in mice. |
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Keywords: | Brain Cyclocreatine Hypoxia Mouse Protection |
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