Survey of the year 2004: literature on applications of isothermal titration calorimetry |
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Authors: | Ababou Abdessamad Ladbury John E |
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Affiliation: | Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. |
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Abstract: | The market for commercially available isothermal titration calorimeters continues to grow as new applications and methodologies are developed. Concomitantly the number of users (and abusers) increases dramatically, resulting in a steady increase in the number of publications in which isothermal titration calorimetry (ITC) plays a role. In the present review, we will focus on areas where ITC is making a significant contribution and will highlight some interesting applications of the technique. This overview of papers published in 2004 also discusses current issues of interest in the development of ITC as a tool of choice in the determination of the thermodynamics of molecular recognition and interaction. |
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Keywords: | isothermal titration calorimetry biomolecular interactions thermodynamics protein‐ligand interactions |
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