Amplifiedbcl-2/JH rearrangements in reactive lymphadenopathy |
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Authors: | Koichi Ohshima Masahiro Kikuchi Shinichi Kobari Yuichi Masuda Fuyuki Eguchi Nobuhiro Kimura |
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Affiliation: | 1. First Department of Pathology, Fukuoka University, Nanakuma 7-45-1, Jyonan-ku, 814-01, Fukuoka, Japan 2. First Department of Internal Medicine, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jyonan-ku, 814-01, Fukuoka, Japan
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Abstract: | Using the polymerase chain reaction (PCR) to examine the occurrence ofbcl-2/JH joining produced by t(14;18) chromosomal translocation, amplified DNA was detected in 2 of 18 lymph nodes showing reactive lymphadenopathy. The PCR was repeated in these two lymphs nodes using the same DNA samples, but no amplification was detected at the second attempt. Thus the amplified DNA was considered to be derived from one copy of joinedbcl-2/JH in one cell, or from a few copies in a few clonal cells with the same joinedbcl-2/JH. These results suggest that false joining ofbcl-2/JH at the t(14;l8) junction may occur in reactive lymph nodes. |
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Keywords: | bcl-2 Reactive lymphadenopathy |
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