Cenp-F (mitosin) is more than a mitotic marker |
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Authors: | Asta Varis Anna-Leena Salmela Marko J. Kallio |
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Affiliation: | 1. Cancer Biology and Cell Screening Department, VTT Medical Biotechnology, It?inen Pitk?katu 4A, 20521, Turku, Finland 2. Centre for Biotechnology, University of Turku, Tykist?katu 6, 20521, Turku, Finland 3. Turku Graduate School of Biomedical Sciences, University of Turku, Turku, Finland
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Abstract: | Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein’s post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed. |
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