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A set of BAC clones spanning the human genome |
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| Authors: | Krzywinski Martin Bosdet Ian Smailus Duane Chiu Readman Mathewson Carrie Wye Natasja Barber Sarah Brown-John Mabel Chan Susanna Chand Steve Cloutier Alison Girn Noreen Lee Darlene Masson Amara Mayo Michael Olson Teika Pandoh Pawan Prabhu Anna-Liisa Schoenmakers Eric Tsai Miranda Albertson Donna Lam Wan Choy Chik-On Osoegawa Kazutoyo Zhao Shaying de Jong Pieter J Schein Jacqueline Jones Steven Marra Marco A |
| Institution: | BC Cancer Agency Genome Sciences Center and BC Cancer Agency, Vancouver, BC V5Z 4E6, Canada. |
| Abstract: | Using the human bacterial artificial chromosome (BAC) fingerprint-based physical map, genome sequence assembly and BAC end sequences, we have generated a fingerprint-validated set of 32 855 BAC clones spanning the human genome. The clone set provides coverage for at least 98% of the human fingerprint map, 99% of the current assembled sequence and has an effective resolving power of 79 kb. We have made the clone set publicly available, anticipating that it will generally facilitate FISH or array-CGH-based identification and characterization of chromosomal alterations relevant to disease. |
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