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Synthesis of the lupane group triterpenoids and there hepatoprotective activity
Authors:Flekhter O B  Karachurina L T  Poroĭkov V V  Nigmatullina L R  Baltina L A  Zarudiĭ F S  Davydova V A  Spirikhin L V  Baĭkova I P  Galin F Z  Tolstikov G A
Affiliation:Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, Bashkortostan, Russia. obf@anrb.ru
Abstract:Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in position 3 and 28 were shown to exhibit a pronounced hepatoprotective effect similar to that of betulin and silibor. These experimental data were in a good agreement with the computer prediction of their biological activity. Betulin 3,28-bis-hemiphthalate was more effective than carsil in models of experimental hepatitis caused by carbon tetrachloride, tetracycline, and ethanol.
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